PRINCESS Project: A breakthrough in fertility research after childhood cancer

On 13 May 2025, the CHU de Liège hosted a significant event dedicated to fertility after pediatric cancer. The gathering brought together clinicians, researchers, healthcare partners, and participants involved in the PRINCESS study — an important milestone in reproductive health research.

Organized by Dr. Bianca David, PhD candidate at the University of Liège (ULiège), under the supervision of Dr. Caroline Piette and Prof. Anne-Simone Parent, the event was held in collaboration with GIGA Neurosciences and supported by the Foundation against Cancer.

PRINCESS (Fertility and Quality of Life After Pediatric Cancer) is a nationwide, multicenter study focused on improving reproductive care for women who have survived childhood cancer. It involves leading institutions across Belgium, including CHU de Liège, ULiège, C.U. Saint-Luc, HUDERF, BCR, BSPHO, and several hospitals and research centers.

Funded by the Foundation against Cancer, the study has received €778,005 for the 2023–2026 period.

Key goals of the study include:

• Investigating how chemotherapy doses affect ovarian function depending on age at treatment
• Assessing the benefits of ovarian tissue cryopreservation across patient profiles
• Identifying early biomarkers of ovarian insufficiency to allow personalized care

Many women who survive pediatric cancer experience long-term effects on their reproductive health. These may include infertility, hormonal disruption, mental health concerns, and increased risks of cardiovascular, bone, cognitive, and sexual health disorders.

By deepening our understanding of these impacts, the PRINCESS study aims to improve the quality of life for survivors and refine clinical approaches to fertility preservation.

The program included:

• Presentation of the PRINCESS research project
• Guided tour of the oncology research laboratory
• Roundtable discussion with study partners
• Informal networking with refreshments

This event marks a shared success in advancing fertility research, made possible by the support of the Foundation against Cancer and the collaboration of medical professionals, researchers, and participants.

Thank you to everyone contributing to this vital work!